Answer: Yes, the WF 2144 is well suited for simulating PT-100 sensors.
Many of our customers use the WF 2144 for PT-100 simulations in for example HIL (Hardware-In-the-Loop) systems.
Check out our application note* for more details.
App note: AN9 - PT100 simulator
Example code: AN9 - PT100 simulator examples (*.zip)
*The application note and example are made based on the WF 3144 Programmable Resistor C Series Module for CompactRIO. However, the same principles applies.